Since I got my first Mewtwo just over a year ago, concluding you don’t have a Shadowball Mewtwo. I imagine your options would be to have your best new one be ice beam or psychic. Ice beam would help against a return of Rayquaza/Latios/Latias.
Psychic could help you do some daily filler solo-raids (Machamp) that you may or may not be able to already easily do. I doubt Kyogre is coming back anytime soon, so I’d not factor in an electric Mewtwo.
My standards for Mewtwo have me pleased with 2250+, however don’t transfer any of them. Keep them to trade. I just traded for one with a new best friend and it went 2235 to 2253 w/o getting lucky (15a/14d/12). All of them are good to catch, have, trade.
I wouldn’t power up a whole squad of them. Think about two or three to a useful level, and maxing not necessarily needed for ones with these new moves. You should collect CTMs, too, so they and you can be more versatile.