I'm wondering the same thing. Here is my impression, curious what others think. This is based of the mons I use against it, mostly 2500CP machamps.
- <2200CP, around level 25 for high IV: Blissey is not much of a defender, I use whatever attacker autoselect is giving me, to save time
- 2500CP/level 27: becomes OK
- 2800CP/level 32: good defender. A Blissey with ZH/DG and my 2500+CP Machamp usually faint around the same, depending on luck with lag and dodging
- 3100CP/level 38: I have to choose a good second attacker.
After gen3 and move rebalance, if nothing changes, I plan to bring all my Blisseys to >2800CP and a few to >3000CP.