The same principles apply, you just have to put in 5 other 10 CP Pokemon, which is a little annoying.
It adds about 5-10 second per cycle, which slows down the xp grind a bit. Bubblestrat is still the fastest way to prestige ingame, because this extra time picking attackers affects everyone, not just Bubblestrat.
For xp, You probably need some friends to help setup a gym with 3+ Bubblestrat defenders. With 5 defenders, the xp rate decreased from 27k/hr to 24k/hr, only slightly. That seems to be the current sweet spot.